Nitric Oxide and Blood–Brain Barrier Integrity

Nitric oxide and the bioactivities

Nitric oxide (NO), previously known as Endothelium-Derived Relaxing Factor (EDRF) is involved in a wide range of physiological and pathophysiological mechanisms. It is synthesized endogenously by the enzymes Nitric Oxide Synthase (NOS) in specialized tissues from its precursor L-arginine, yielding L-citrulline as a byproduct. It is released by a family of isoenzymes, viz., the endothelial (eNOS...

Nitric oxide and the bioactivities

Nitric oxide (NO), previously known as Endothelium-Derived Relaxing Factor (EDRF) is involved in a wide range of physiological and pathophysiological mechanisms. It is synthesized endogenously by the enzymes Nitric Oxide Synthase (NOS) in specialized tissues from its precursor L-arginine, yielding L-citrulline as a byproduct. It is released by a family of isoenzymes, viz., the endothelial (eNOS...

Regulation of blood-brain barrier endothelial cells by nitric oxide.

Nitric oxide (NO) synthesized by vascular endothelial cells is a potent vasodilator substance. The actions of NO extend well beyond its vasodilatory properties, and increasingly, NO has been recognized as an important signal for intercellular and intracellular communication. Recently, NO has been implicated in the regulation of vascular and blood-brain barrier permeability. NO has also been sho...

Nitric Oxide Production and Nitric Oxide

Perspective Series: Nitric Oxide and Nitric Oxide Synthases Nitric Oxide Synthases: Which, Where, How, and Why?

Although nitric oxide (NO) 1 may not modulate all cellular functions and may not be present in all mammalian cells, the sheer volume of publications on the subject might lead one to conclude that this diminutive molecule is both omnipotent and omnipresent in human biology. This series of four Perspective articles, in the current and following issues of The Journal of Clinical Investigation , wi...